[Gate-users] Voxelised Source Placement Confusion

Tue Jul 12 17:32:00 CEST 2022

Hi Mark,

Have you had any progress? What GATE version are you using by the way? I did some tests myself, and it seems that voxelized sources are either broken in GATE v9.2 or then the documentation is outdated. The shift that worked previously (at least in 8.2), now shifts the source in completely different location. In fact, using the original rule, the source seems to be shifted completely out of the scanner FOV in the current version.

Has the voxelized source example been tested/validated for the current version?

Regards,
Ville-Veikko Wettenhovi
________________________________
From: Ville-Veikko Wettenhovi <ville-veikko.wettenhovi at uef.fi>
Sent: Wednesday, June 29, 2022 10:59
To: BAKER, Mark (THE CLATTERBRIDGE CANCER CENTRE NHS FOUNDATION TRUST) <mark.baker23 at nhs.net>; gate-users at lists.opengatecollaboration.org <gate-users at lists.opengatecollaboration.org>
Subject: Re: Voxelised Source Placement Confusion

Hi Mark,

Sorry for the late response. I've not used DICOM images myself with GATE ever so I really can't comment them. One possibility is if you convert the DICOM images into interfile or MetaImage files and then try again. Those have always worked fine in my case.

Regards,
Ville-Veikko Wettenhovi
________________________________
From: BAKER, Mark (THE CLATTERBRIDGE CANCER CENTRE NHS FOUNDATION TRUST) <mark.baker23 at nhs.net>
Sent: Thursday, June 23, 2022 14:55
To: BAKER, Mark (THE CLATTERBRIDGE CANCER CENTRE NHS FOUNDATION TRUST) <mark.baker23 at nhs.net>; Ville-Veikko Wettenhovi <ville-veikko.wettenhovi at uef.fi>; gate-users at lists.opengatecollaboration.org <gate-users at lists.opengatecollaboration.org>
Subject: RE: Voxelised Source Placement Confusion

Hi Ville-Veikko (and everyone else)

Apologies for the delay in getting this data back, I’ve not had much project time recently. I’ve attached a single slice from each of the PET and CT data, and as far as I can tell, the data looks correct.

Thank you

Mark Baker

Principal Clinical Scientist

Imaging Physics (Ionising)

The Clatterbridge Cancer Centre NHS Foundation Trust

(he, him)

CCCW Tel:  0151 556 5030

CCCL Tel: 0151 318 8438

Email: mark.baker23 at nhs.net<mailto:mark.baker23 at nhs.net>

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From: Gate-users <gate-users-bounces at lists.opengatecollaboration.org> On Behalf Of BAKER, Mark (THE CLATTERBRIDGE CANCER CENTRE NHS FOUNDATION TRUST)
Sent: 17 June 2022 09:27
To: Ville-Veikko Wettenhovi <ville-veikko.wettenhovi at uef.fi>; gate-users at lists.opengatecollaboration.org
Subject: Re: [Gate-users] Voxelised Source Placement Confusion

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I think so. I got the information direct from the header files, with both imageJ and Weasis. I’m away from my data at the moment, but when I am back I’ll attach a sample slice with the header attached, in case I’m being a complete numpty.

Thank you

Mark Baker

Principal Clinical Scientist (Interim)

Imaging Physics (Ionising)

The Clatterbridge Cancer Centre NHS Foundation Trust

(he, him)

CCCW Tel:  0151 556 5030

CCCL Tel: 0151 318 8438

Email: mark.baker23 at nhs.net<mailto:mark.baker23 at nhs.net>

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From: Ville-Veikko Wettenhovi <ville-veikko.wettenhovi at uef.fi<mailto:ville-veikko.wettenhovi at uef.fi>>
Sent: 16 June 2022 15:23
To: BAKER, Mark (THE CLATTERBRIDGE CANCER CENTRE NHS FOUNDATION TRUST) <mark.baker23 at nhs.net<mailto:mark.baker23 at nhs.net>>; gate-users at lists.opengatecollaboration.org<mailto:gate-users at lists.opengatecollaboration.org>
Subject: Re: Voxelised Source Placement Confusion

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Hi Mark,

The macros seem fine. Are you sure the relevant dimensions and the size of voxels are present and correct in the PET data header file?

Regards,

Ville-Veikko Wettenhovi

________________________________

From: BAKER, Mark (THE CLATTERBRIDGE CANCER CENTRE NHS FOUNDATION TRUST) <mark.baker23 at nhs.net<mailto:mark.baker23 at nhs.net>>
Sent: Thursday, June 16, 2022 17:08
To: Ville-Veikko Wettenhovi <ville-veikko.wettenhovi at uef.fi<mailto:ville-veikko.wettenhovi at uef.fi>>; gate-users at lists.opengatecollaboration.org<mailto:gate-users at lists.opengatecollaboration.org> <gate-users at lists.opengatecollaboration.org<mailto:gate-users at lists.opengatecollaboration.org>>
Subject: RE: Voxelised Source Placement Confusion

Hi Ville-Veikko

Thank you for your reply. The relevants macs are attached to this email. I have 8 mains in total (one for each core) which are identical apart from the first one has visualisation. The current offset was just something I was trying but I can’t seem to get any of the numbers to truly work.

Thank you

Mark Baker

Principal Clinical Scientist

Imaging Physics (Ionising)

The Clatterbridge Cancer Centre NHS Foundation Trust

(he, him)

CCCW Tel:  0151 556 5030

CCCL Tel: 0151 318 8438

Email: mark.baker23 at nhs.net<mailto:mark.baker23 at nhs.net>

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From: Ville-Veikko Wettenhovi <ville-veikko.wettenhovi at uef.fi<mailto:ville-veikko.wettenhovi at uef.fi>>
Sent: 16 June 2022 14:46
To: BAKER, Mark (THE CLATTERBRIDGE CANCER CENTRE NHS FOUNDATION TRUST) <mark.baker23 at nhs.net<mailto:mark.baker23 at nhs.net>>; gate-users at lists.opengatecollaboration.org<mailto:gate-users at lists.opengatecollaboration.org>
Subject: Re: Voxelised Source Placement Confusion

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Hi Mark,

Moving the voxelized source by half of each dimension should indeed work and has worked in the cases where I've used voxelized source. Could you share the part of the macro where you define and move the voxelized source?

Another way to determine the positioning could be to form the "ground truth" image of the trues, i.e. an image where the coincidences are accumulated based on their source locations. Then compare that image to the attenuation image from the attenuation map actor (both with the same dimensions).

Regards,

Ville-Veikko Wettenhovi

________________________________

From: Gate-users <gate-users-bounces at lists.opengatecollaboration.org<mailto:gate-users-bounces at lists.opengatecollaboration.org>> on behalf of BAKER, Mark (THE CLATTERBRIDGE CANCER CENTRE NHS FOUNDATION TRUST) <mark.baker23 at nhs.net<mailto:mark.baker23 at nhs.net>>
Sent: Thursday, June 16, 2022 16:27
To: gate-users at lists.opengatecollaboration.org<mailto:gate-users at lists.opengatecollaboration.org> <gate-users at lists.opengatecollaboration.org<mailto:gate-users at lists.opengatecollaboration.org>>
Subject: [Gate-users] Voxelised Source Placement Confusion

Hi all

I raised this query a while (or one similar) but unfortunately, I’ve not managed to get back around to my project for a while. In short, I can’t get good alignment between my CT and PET images. My understanding is that the voxelised PET source image should be offset by half of its size to account for it being placed in the corner of the world instead of the centre where the CT image is place. My world is 1 1 2 m and my CT data is 780 780 693 mm (512x512x213 matrix). My PET data is 814.568 814.568 639 mm (200x200x213 matrix).

I think I was a bit confused at first, and was moving the PET source by half of its own size but then I re-read the ReadTheDocs and I think it is suggesting that I actually need to move the PET image by half of the world size (setPosition -500 -500 -1000 mm) but this results in a large offset. I’ve tried various combinations of half the size of the world, half the size of the PET data etc. and I think I’m just going around in circles now. Logically, I feel like the solution is that I move half of the world size at first to move the corner of the PET data into the centre of the world, then back by half of the PET image to put the centre of the PET in the centre of the world, but it is still offset. Any suggestions, as I’m tearing my hair out a little now.

Additionally, in order to test where the positioning is correct, I’m relying on the generation of secondary electrons within the water phantom in my image and looking at the NbofHits file produced. This works fine when the difference is obvious between the two, but I wonder if there is a better way to see the isocentre in order to 100% confirm it is correct? The reason I use secondary electrons is that positrons and gammas flood the image making it impossible to see the underlying CT data, plus I expect the secondary electrons to largely be created in the water and not air.

Thank you in advance!

Mark Baker

Principal Clinical Scientist

Imaging Physics (Ionising)

The Clatterbridge Cancer Centre NHS Foundation Trust

(he, him)

CCCW Tel:  0151 556 5030

CCCL Tel: 0151 318 8438

Email: mark.baker23 at nhs.net<mailto:mark.baker23 at nhs.net>

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University of Liverpool

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