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Hi <span style="font-family:arial, helvetica, sans-serif;font-size:15px;background-color:rgb(255, 255, 255)" class="ContentPasted0">
Nícollas, </span></div>
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<span style="font-family:arial, helvetica, sans-serif;font-size:15px;background-color:rgb(255, 255, 255)" class="ContentPasted0"><br>
</span></div>
<div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
<span style="font-family:arial, helvetica, sans-serif;font-size:15px;background-color:rgb(255, 255, 255)" class="ContentPasted0"><span style="background-color:rgb(255, 255, 255);display:inline !important" class="ContentPasted4">I calculated the dose in each
organ (in mGy) from Edep and then divided by the activity*time for S-Factors in mGy/MBq s. </span></span></div>
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<span style="font-family:arial, helvetica, sans-serif;font-size:15px;background-color:rgb(255, 255, 255)" class="ContentPasted0">I was just running the simulation for a fixed activity for 1 second. I used the rangeTranslator in Gate to set an
<span style="background-color:rgb(255, 255, 255);display:inline !important">ActivityRange.dat</span> file with the Bq/voxel in each region of the image <span style="background-color:rgb(255, 255, 255);display:inline !important" class="ContentPasted5">so I knew
the total activity in each source region</span></span><span style="font-family: arial, helvetica, sans-serif; font-size: 15px;">: </span></div>
<div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
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</span></div>
<div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
<span style="font-family:arial, helvetica, sans-serif;font-size:15px;background-color:rgb(255, 255, 255)" class="ContentPasted0 ContentPasted2">/gate/source/NAME/reader/insert image<br>
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<div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
<span style="font-family:arial, helvetica, sans-serif;font-size:15px;background-color:rgb(255, 255, 255)" class="ContentPasted0 ContentPasted1">/gate/source/NAME/imageReader/translator/insert range
<div class="ContentPasted1">/gate/source/NAME/imageReader/rangeTranslator/readTable ActivityRange.dat</div>
/gate/source/NAME/imageReader/rangeTranslator/describe 1<br>
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<span style="font-family:arial, helvetica, sans-serif;font-size:15px;background-color:rgb(255, 255, 255)" class="ContentPasted0 ContentPasted3">/gate/source/<span style="background-color:rgb(255, 255, 255);display:inline !important">NAME</span>/imageReader/readFile
source_image.h33<br class="ContentPasted3">
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<div class="elementToProof"><span style="font-family: Arial, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">I assume that y</span><span style="font-family: Arial, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">ou could use the
number of </span><span style="font-family: Arial, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);">primaries</span><span style="font-family: Arial, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);"> for the division instead of the
activity*time, but I haven't tried that function with voxelised phantoms so I am not sure how the activity gets distributed.</span></div>
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<span style="font-family:arial, helvetica, sans-serif;font-size:15px;background-color:rgb(255, 255, 255)" class="ContentPasted0 ContentPasted3">Best wishes,</span></div>
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</span></font></div>
<div style="color: rgb(0, 0, 0);" class="elementToProof"><span style="font-family: arial, helvetica, sans-serif; font-size: 15px; background-color: rgb(255, 255, 255);" class="ContentPasted0 ContentPasted3">
<div class="elementToProof">Sophia Pells</div>
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<div id="divRplyFwdMsg" dir="ltr"><font face="Calibri, sans-serif" style="font-size:11pt" color="#000000"><b>From:</b> Nicollas Goncalves Cavedini <nicollas.cavedini@acad.pucrs.br><br>
<b>Sent:</b> Wednesday, October 19, 2022 22:28<br>
<b>To:</b> Sophia Pells <sophia.pells@manchester.ac.uk><br>
<b>Cc:</b> gate-users@lists.opengatecollaboration.org <gate-users@lists.opengatecollaboration.org><br>
<b>Subject:</b> Re: [Gate-users] S-Values and DoseActor issues (Nicollas Goncalves Cavedini)</font>
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<div dir="ltr">Hi Sophia!
<div><br>
<div>Firstly, thanks for your detailed answer to my questions! About the "Ion Source", this publication by Julia Brosch is the same that I read. I was hoping that the people working in GATE development know if this bug was corrected.</div>
<div><br>
</div>
<div>About the Edep and S-Values, I was using the organ's mass and Edep for the dose calculation but how can I calculate the S-value? Should I get the division of the dose by the accumulated activity and later divide it by the number of primaries (/gate/application/setTotalNumberOfPrimaries)?</div>
<div><br>
</div>
<div>I greatly appreciate your help!</div>
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<div><font color="#000000"><b style="font-family:arial,helvetica,sans-serif">Best regards,</b><br>
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<div><font face="arial, helvetica, sans-serif" color="#000000"><b><br>
</b></font></div>
<div dir="ltr"><font face="arial, helvetica, sans-serif" color="#000000"><b>Nícollas Gonçalves Cavedini</b></font>
<div>
<div dir="ltr"><font color="#000000">BSc in Physics - PUCRS<br>
</font></div>
<div style="font-size:12.8px">
<div style="font-size:small"><font color="#000000">M. Eng. in Electrical Engineering - PUCRS</font></div>
<div style="font-size:small"><font color="#000000">PhD student in Biomedical Gerontology - PUCRS</font></div>
<div style="font-size:small"><font color="#000000"><br>
</font></div>
</div>
</div>
<div><span style="color:rgb(0,0,0)">Medical Image Computing Laboratory (MEDICOM)</span><br style="color:rgb(0,0,0)">
</div>
<div><font face="arial, helvetica, sans-serif" color="#000000">Contact: +55 (51) 99922-9957</font></div>
<div><span style="font-family:arial,helvetica,sans-serif"><font color="#000000">Porto Alegre, Brazil.</font></span><br>
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<div dir="ltr" class="x_gmail_attr">Em qua., 19 de out. de 2022 às 11:18, Sophia Pells <<a href="mailto:sophia.pells@manchester.ac.uk" target="_blank">sophia.pells@manchester.ac.uk</a>> escreveu:<br>
</div>
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Hi N<span style="font-size:14.6667px; background-color:rgb(255,255,255); display:inline">í</span>collas, </div>
<div style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)">
<br>
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<div style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)">
I've calculated S-factors for Lu-177 in Gatev8.2 before so I will have a go at answering your questions: </div>
<div style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)">
<br>
</div>
<div>1<span style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)">) Is the "Ion Source" recommended for this?</span><br>
</div>
<div><span style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)">There have been reported issues with the ion source for Lu-177 in some versions of Geant4, particularly v10.5.0 (see </span><a href="http://lists.opengatecollaboration.org/pipermail/gate-users/2019-November/011175.html" target="_blank"><span style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt">http://lists.opengatecollaboration.org/pipermail/gate-users/2019-November/011175.html</span></a><span style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)">).
It may have been fixed in later versions but I would still recommend using a UserSpectrum and defining the source yourself so you know exactly what photon, beta, mono-energetic electron data is being used (the mono-energetic electron emission energies and
intensities especially vary quite a bit with different data sources). </span></div>
<div><br>
</div>
<div><span style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)">2)</span><span style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)"> </span><span style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)">)
Is the "DoseActor" the best way to record the dose?</span><br>
</div>
<div><span style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)">I used the DoseActor, but found the Edep output was more useful than the Dose output
<span style="background-color:rgb(255,255,255); display:inline">(for my applications)<span> </span></span>. This gives the energy deposited in each voxel (in MeV). It can be enabled with the commands:</span></div>
<div><br>
</div>
<div>
<div><span style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)">/gate/actor/NAME/enableEdep true</span></div>
<div><span style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)">/gate/actor/NAME/enableUncertaintyEdep true</span><br>
</div>
<div><br>
</div>
<div><span style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)">Note that the uncertainty is
</span><span style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)"><b>relative</b></span><span style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)">. </span></div>
<div><br>
</div>
<div><span style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)">3) How do I calculate the S-values?</span><span style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)"> </span><br>
</div>
<div><span style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)">The Edep output gives the energy deposited in each voxel of the image. I would use a set of VOIs and ImageJ to get the total energy deposited in each organ (sum
over the slices) and use that with the organ mass to calculate the dose and S-factors. I had to run each source organ as a separate simulation due to memory limitations and then sum the contribution from each source region for each target region. I would
recommend avoiding the particleFilter actor as I got some weird results with this (they might have been fixed since I used it). I would just run separate simulations to get the separate contribution from photons, betas etc. </span></div>
<div style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)">
<br>
</div>
</div>
<div style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)">
OpenDose is a great resource for S-factors. I validated my simulations by downloading the ICRP 110 AF phantom and comparing my S-factors with the ones on OpenDose. </div>
<div style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)">
<a href="https://www.opendose.org/svalues" id="x_m_2666268155331775282m_7978918138330027537LPNoLPOWALinkPreview" target="_blank">https://www.opendose.org/svalues</a><br>
</div>
<div></div>
<br>
<div style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)">
<span style="color:rgb(0,0,0); font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt">Hope this helps! </span><br>
</div>
<div><br>
</div>
<div><span style="font-family:Calibri,Arial,Helvetica,sans-serif; font-size:12pt; color:rgb(0,0,0)">Best wishes, </span></div>
<div><br>
</div>
<div>Sophia </div>
<div id="x_m_2666268155331775282m_7978918138330027537signature_bookmark"></div>
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<div id="x_m_2666268155331775282m_7978918138330027537divRplyFwdMsg" dir="ltr"><font face="Calibri, sans-serif" color="#000000" style="font-size:11pt"><b>From:</b> Gate-users <<a href="mailto:gate-users-bounces@lists.opengatecollaboration.org" target="_blank">gate-users-bounces@lists.opengatecollaboration.org</a>>
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<b>Sent:</b> Wednesday, October 19, 2022 11:00<br>
<b>To:</b> <a href="mailto:gate-users@lists.opengatecollaboration.org" target="_blank">
gate-users@lists.opengatecollaboration.org</a> <<a href="mailto:gate-users@lists.opengatecollaboration.org" target="_blank">gate-users@lists.opengatecollaboration.org</a>><br>
<b>Subject:</b> Gate-users Digest, Vol 197, Issue 6</font>
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Today's Topics:<br>
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1. S-Values and DoseActor issues (Nicollas Goncalves Cavedini)<br>
<br>
<br>
----------------------------------------------------------------------<br>
<br>
Message: 1<br>
Date: Tue, 18 Oct 2022 08:31:29 -0300<br>
From: Nicollas Goncalves Cavedini <<a href="mailto:nicollas.cavedini@acad.pucrs.br" target="_blank">nicollas.cavedini@acad.pucrs.br</a>><br>
To: gate-users <<a href="mailto:Gate-users@lists.opengatecollaboration.org" target="_blank">Gate-users@lists.opengatecollaboration.org</a>><br>
Subject: [Gate-users] S-Values and DoseActor issues<br>
Message-ID:<br>
<CAMTcvva3g8_War69zqXf=<a href="mailto:JTT7CBUo77VTXsmWgitpz7Nywfv%2BA@mail.gmail.com" target="_blank">JTT7CBUo77VTXsmWgitpz7Nywfv+A@mail.gmail.com</a>><br>
Content-Type: text/plain; charset="utf-8"<br>
<br>
Dear GATE Users, I am sending this email again as I have not received a<br>
response.<br>
<br>
I am working on my PhD project with PET/CT images of prostate cancer and I<br>
have some questions about anthropomorphic phantom simulations. I intend to<br>
perform simulations with 177Lu using the "Golem" phantom from GSF Family.<br>
<br>
My questions are:<br>
1) Is the "Ion Source" recommended for this?<br>
<br>
2) Is the "DoseActor" the best way to record the dose? I was searching in<br>
the previous e-mails and I have found a report that the DoseActor may not<br>
be the most suitable resource for this application.<br>
<br>
3) How do I calculate the S-values? For each simulation, I get the absorbed<br>
dose in each organ, but how do I "transform" this into S-values? We have<br>
PET images with 4 time points after the injection and I can extract the<br>
accumulated activity (Ã).<br>
<br>
Any help is appreciated!<br>
<br>
*Atenciosamente,*<br>
<br>
*Nícollas Gonçalves Cavedini*<br>
BSc in Physics - PUCRS<br>
M. Eng. in Electrical Engineering - PUCRS<br>
PhD student in Biomedical Gerontology - PUCRS<br>
<br>
Medical Image Computing Laboratory (MEDICOM)<br>
Contact: +55 (51) 99922-9957<br>
Porto Alegre, Brazil.<br>
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