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<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D">Hi !<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D">Sorry, I did not have time to go through your macros, but you also said “</span>I did not find the example where DoseActor is used to record energy deposited
by ions for dosimetry<span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D">”<o:p></o:p></span></p>
<p class="MsoListParagraph" style="text-indent:-.25in;mso-list:l0 level1 lfo4"><![if !supportLists]><span style="font-size:11.0pt;font-family:Wingdings;color:#1F497D"><span style="mso-list:Ignore">è<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D">You can find it under
</span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D">the
<a href="https://eur03.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2FOpenGATE%2FGateContrib%2Ftree%2Fmaster%2FGATE-RTion&data=04%7C01%7Cloic.grevillot%40medaustron.at%7C991a8c8daae94bce6fbc08d8e03752cf%7Cadb749e06dfd4f6fbea8cd9f8e0c9b89%7C0%7C0%7C637505876735190754%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=ggXJ1p8887dT%2FsE8jSOOZVsHivOVWG91KQ1M%2FTCNiGw%3D&reserved=0" target="_blank">
gitcontrib</a> repository, in DoseActor (scrren-shots below)</span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><o:p></o:p></span></p>
<p class="MsoListParagraph" style="text-indent:-.25in;mso-list:l0 level1 lfo4"><![if !supportLists]><span style="font-size:11.0pt;font-family:Wingdings;color:#1F497D"><span style="mso-list:Ignore">è<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D">You can find an example of energy to dose conversion validation for ions – further testing include mass-weighting, volume-weighting algorithms, etc.
are also available.</span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><img border="0" width="616" height="306" id="Picture_x0020_2" src="cid:image001.jpg@01D71424.682C2260"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D">
</span><img border="0" width="651" height="400" id="Picture_x0020_4" src="cid:image002.jpg@01D71424.682C2260"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><o:p></o:p></span></p>
<p class="MsoListParagraph"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoListParagraph"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><img border="0" width="765" height="760" id="Picture_x0020_1" src="cid:image003.jpg@01D71424.682C2260"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D">Best,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D">Loïc<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">From:</span></b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"> Albert Grace Lieu [mailto:albertnew2018@gmail.com]
<br>
<b>Sent:</b> Saturday, March 6, 2021 1:27 AM<br>
<b>To:</b> Grevillot Loic <loic.grevillot@medaustron.at>; gate-users <gate-users@lists.opengatecollaboration.org><br>
<b>Cc:</b> Peter Olcott <polcott@reflexion.com><br>
<b>Subject:</b> Re: Potential bug report of Edep in DoseActor (Edep always == 1 Mev for any Ion)<o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal">Hi Loïc,<o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal">Thank you very much for actively answering DoseActor related questions in the past ten years. I saw your answers in the GATE archive quite often. I did read through almost all example codes in GATE-RTiON, but I did not find the example
where DoseActor is used to record energy deposited by ions for dosimetry. <o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal">Here is the problem I have found with Edep in DoseActor,<a href="https://eur03.safelinks.protection.outlook.com/?url=http%3A%2F%2Flists.opengatecollaboration.org%2Fpipermail%2Fgate-users%2F2009-July%2F003406.html&data=04%7C01%7Cloic.grevillot%40medaustron.at%7C991a8c8daae94bce6fbc08d8e03752cf%7Cadb749e06dfd4f6fbea8cd9f8e0c9b89%7C0%7C0%7C637505876735180759%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=GVfn7d0HY3KvSz1EbfNrBCt9r6FcT%2FbbHW%2FRN1BUIrw%3D&reserved=0" target="_blank">
a similar question</a> was also asked many years ago. No matter what source I use, like I-131, Lu-177, Edep in DoseActor always returns
<b>1 (Mev) per disintegration</b>. Dose in DoseActor also utilizes the value returned Edep, which leads to a wrong result. I would rather believe that I made a mistake somewhere than think GATE's DoseActor failed in my case. <o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<div>
<p class="MsoNormal">Could you or any other GATE user have a look at my code? It is self-containt code. You will finish the entire verification in less than 5 minutes. Here is what the GATE code does: <o:p></o:p></p>
</div>
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<div>
<ul type="disc">
<li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l1 level1 lfo1">
Phantom: 101*101*101 voxelized tissue ( water equivalent) phantom, with a side of 2 mm for each voxel <o:p></o:p></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l1 level1 lfo1">
Source: 10 mm radius sphere voxelized Lu177 source with a side of 2 mm for each voxel, and being placed in the center of the phantom<o:p></o:p></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l1 level1 lfo1">
DoseActor: record dose, Edep, and export a mass image of the phantom (all 3D array)<o:p></o:p></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l1 level1 lfo1">
ProductionAndStoppingActor: record the number of Lu177 generated in each voxel, indicated by Lu177-Stop (3D array)
<o:p></o:p></li></ul>
<div>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"> According to the user manual, "The unit of edep is MeV and the unit of dose is Gy". <o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><o:p> </o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">You will also find a python script (result-analysis.ipynb) to do the analysis:<o:p></o:p></p>
<ul type="disc">
<li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l3 level1 lfo2">
reads dose, edep, mass, and particle-prod<o:p></o:p></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l3 level1 lfo2">
calculate the average energy deposited by a single disintegration.<o:p></o:p></li></ul>
<div>
<p class="MsoNormal">Thank you very much for any help and verification. <o:p></o:p></p>
</div>
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<p class="MsoNormal"><o:p> </o:p></p>
</div>
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<p class="MsoNormal">Albert<o:p></o:p></p>
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<p class="MsoNormal">On Fri, Mar 5, 2021 at 12:48 AM Grevillot Loic <<a href="mailto:loic.grevillot@medaustron.at" target="_blank">loic.grevillot@medaustron.at</a>> wrote:<o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="DE" style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D">FYI,</span><span lang="DE"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D">DoseActor validation tests were provided for the
<a href="https://eur03.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgate.uca.fr%2Fdownload%2Fgate-rtion&data=04%7C01%7Cloic.grevillot%40medaustron.at%7C991a8c8daae94bce6fbc08d8e03752cf%7Cadb749e06dfd4f6fbea8cd9f8e0c9b89%7C0%7C0%7C637505876735180759%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=Zn97wCKsFa%2BxCi3%2BYO%2F2hLVeY9%2BUf9jOfKAxU3xP1x4%3D&reserved=0" target="_blank">
GATE-RTiON</a> release, in the context of light ion beam therapy under the <a href="https://eur03.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2FOpenGATE%2FGateContrib%2Ftree%2Fmaster%2FGATE-RTion&data=04%7C01%7Cloic.grevillot%40medaustron.at%7C991a8c8daae94bce6fbc08d8e03752cf%7Cadb749e06dfd4f6fbea8cd9f8e0c9b89%7C0%7C0%7C637505876735190754%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=ggXJ1p8887dT%2FsE8jSOOZVsHivOVWG91KQ1M%2FTCNiGw%3D&reserved=0" target="_blank">
gitcontrib</a> repository.</span><span lang="DE"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D">The tests can be applied in principle to any GATE release and may help you as a starting point.</span><span lang="DE"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D">It would be nice to increase the collection of tests for other clinical applications such as yours!</span><span lang="DE"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"> </span><span lang="DE"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="FR" style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D">Best,</span><span lang="DE"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="FR" style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D">Loïc</span><span lang="DE"><o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">From:</span></b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"> Gate-users [mailto:<a href="mailto:gate-users-bounces@lists.opengatecollaboration.org" target="_blank">gate-users-bounces@lists.opengatecollaboration.org</a>]
<b>On Behalf Of </b>Albert Grace Lieu<br>
<b>Sent:</b> Freitag, 5. März 2021 05:59<br>
<b>To:</b> gate-users <<a href="mailto:gate-users@lists.opengatecollaboration.org" target="_blank">gate-users@lists.opengatecollaboration.org</a>><br>
<b>Subject:</b> [Gate-users] Edep returned by DoseActor is about 7 times bigger then hand calculated value</span><span lang="DE"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="DE"> <o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="DE">Hi Gate users, <o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="DE"> <o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="DE">I am validating the validity of DoseActor in GATE for radionuclide dosimetry application. Surprisingly, I found the Edep returned by DoseActor is about 7 times bigger
than my hand calculated value, so does the dose returned by DoseActor. I could be wrong, but I double-checked everything I did and had been as prudent as I can before asking for suggestions here. <o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="DE"> <o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="DE">Here is what I did in GATE:<o:p></o:p></span></p>
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<span lang="DE">Phantom: 101*101*101 voxelized tissue ( water equivalent) phantom, with a side of 2 mm for each voxel <o:p></o:p></span></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l2 level1 lfo3">
<span lang="DE">Source: 10 mm radius sphere voxelized Lu177 source with a side of 2 mm for each voxel, and being placed in the center of the phantom<o:p></o:p></span></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l2 level1 lfo3">
<span lang="DE">DoseActor: record dose, Edep, and export a mass image of the phantom (all 3D array)<o:p></o:p></span></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l2 level1 lfo3">
<span lang="DE">ProductionAndStoppingActor: record the number of Lu177 generated in each voxel, indicated by Lu177-Stop (3D array)
<o:p></o:p></span></li></ul>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="DE"> According to the user manual, "The unit of edep is MeV and the unit of dose is Gy". <o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="DE"> <o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="DE">Here is how I calculate the average of the energy of Lu177 in water, Lu177 is a beta emitter, the range of electron in water is way smaller than 2mm, thus it is
stopped where is created. Given the branching ratio of Lu177, on average a single Lu177 disintegration would deposit 134.16 Kev (electrons only) or 162.95 Kev (electrons and gammas).<o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="DE"> <o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="DE"><img border="0" width="279" height="181" id="m_7937145216447734549gmail-m_745001018199457084_x005f_x0000_i1025" src="cid:image004.png@01D71424.682C2260" alt="RTEmagicC_Lu-177_decays.png.png"><o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="DE"> <o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="DE">However, when I divide Edep by Lu177-Stop, the energy per Lu177 disintegration returned by DoseActor is
<span style="color:red">~1.0 Mev</span>, which <span style="color:red">7</span> times bigger than my hand calculated value. Is this an internal issue? I attach my Gate code for your review. <o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="DE"> <o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="DE"> <o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="DE">Thanks a lot for your help. <o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="DE">Sincere wishes, <o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="DE">Stay safe and healthy<o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="DE">Albert <o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="DE"> <o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="DE"> <o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><b><span lang="EN-GB" style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:#112359">Disclaimer:</span></b><span lang="DE" style="font-size:10.0pt"><br>
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