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<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:EN-US">FYI,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:EN-US">DoseActor validation tests were provided for the
<a href="https://gate.uca.fr/download/gate-rtion">GATE-RTiON</a> release, in the context of light ion beam therapy under the
<a href="https://github.com/OpenGATE/GateContrib/tree/master/GATE-RTion">gitcontrib</a> repository.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:EN-US">The tests can be applied in principle to any GATE release and may help you as a starting point.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:EN-US">It would be nice to increase the collection of tests for other clinical applications such as yours!<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="FR" style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D">Best,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="FR" style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D">Loïc<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri",sans-serif">From:</span></b><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri",sans-serif"> Gate-users [mailto:gate-users-bounces@lists.opengatecollaboration.org]
<b>On Behalf Of </b>Albert Grace Lieu<br>
<b>Sent:</b> Freitag, 5. März 2021 05:59<br>
<b>To:</b> gate-users <gate-users@lists.opengatecollaboration.org><br>
<b>Subject:</b> [Gate-users] Edep returned by DoseActor is about 7 times bigger then hand calculated value<o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal">Hi Gate users, <o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal">I am validating the validity of DoseActor in GATE for radionuclide dosimetry application. Surprisingly, I found the Edep returned by DoseActor is about 7 times bigger than my hand calculated value, so does the dose returned by DoseActor.
I could be wrong, but I double-checked everything I did and had been as prudent as I can before asking for suggestions here. <o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal">Here is what I did in GATE:<o:p></o:p></p>
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<li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1">
Phantom: 101*101*101 voxelized tissue ( water equivalent) phantom, with a side of 2 mm for each voxel <o:p></o:p></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1">
Source: 10 mm radius sphere voxelized Lu177 source with a side of 2 mm for each voxel, and being placed in the center of the phantom<o:p></o:p></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1">
DoseActor: record dose, Edep, and export a mass image of the phantom (all 3D array)<o:p></o:p></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1">
ProductionAndStoppingActor: record the number of Lu177 generated in each voxel, indicated by Lu177-Stop (3D array)
<o:p></o:p></li></ul>
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<p class="MsoNormal"> According to the user manual, "The unit of edep is MeV and the unit of dose is Gy". <o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal">Here is how I calculate the average of the energy of Lu177 in water, Lu177 is a beta emitter, the range of electron in water is way smaller than 2mm, thus it is stopped where is created. Given the branching ratio of Lu177, on average a
single Lu177 disintegration would deposit 134.16 Kev (electrons only) or 162.95 Kev (electrons and gammas).<o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal"><img border="0" width="279" height="181" id="_x0000_i1025" src="cid:image001.png@01D711A4.BBA8F580" alt="RTEmagicC_Lu-177_decays.png.png"><o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal">However, when I divide Edep by Lu177-Stop, the energy per Lu177 disintegration returned by DoseActor is
<span style="color:red">~1.0 Mev</span>, which <span style="color:red">7</span> times bigger than my hand calculated value. Is this an internal issue? I attach my Gate code for your review. <o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal">Thanks a lot for your help. <o:p></o:p></p>
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<p class="MsoNormal">Sincere wishes, <o:p></o:p></p>
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<p class="MsoNormal">Stay safe and healthy<o:p></o:p></p>
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<p class="MsoNormal">Albert <o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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