<div dir="auto">Hello, Gate users, </div><div dir="auto"><br></div><div dir="auto">We just have a  relatively simple task of estimating internal radiation dosimetry of 18F-labeled PET tracer using doseactor, voxelized phantom and source. However, me and my colleagues are struggling with this beautiful research tool because of lack of experiences and not enough understandings about it. </div><div dir="auto"><br></div><div dir="auto">We acquired PET/CT images using the radiotracer at varying time points to describe the biodistribution of the tracer. CT images were the voxelized phantom and PET images were the matched voxelized source. </div><div dir="auto"><br></div><div dir="auto">By following to many contributors’ exercices and examples, we’ve finally generated following macro that returns common outputs of internal dosimetry by GATE (i.e., Dose and Edep, etc). </div><div dir="auto"><br></div><div dir="auto">Our questions are obvious: </div><div dir="auto"><br></div><div dir="auto">1) is the following macro defined well to generate Dose and Edep map for given voxelized phantom and source?</div><div dir="auto"><br></div><div dir="auto">2) definition of the fluorine-18 was appropriate? </div><div dir="auto"><br></div><div dir="auto">3) how could we measure dose of a specific organ, such as kidney, using dose map? Could it be done by common VOI analysis measuring voxel mean value? </div><div dir="auto"><br></div><div dir="auto">4) the latest simulation gave us non-sense results of showing continuously increasing dose in a organ, while the radioactivity is apparently decreasing as time. how could it be explained? </div><div dir="auto"><br></div><div dir="auto">Best wishes, and have a great weekend! </div><div dir="auto"><br></div><div dir="auto">Park</div><div dir="auto"><br></div><div dir="auto">#=====================================================</div><div dir="auto"># VEROBOSITY</div><div dir="auto">#=====================================================</div><div dir="auto"><br></div><div dir="auto">/control/execute  mac/verbose.mac</div><div dir="auto"><br></div><div dir="auto">#=====================================================</div><div dir="auto"># VISUALISATION</div><div dir="auto">#=====================================================</div><div dir="auto"><br></div><div dir="auto">/control/execute mac/visu.mac</div><div dir="auto"><br></div><div dir="auto">#=====================================================</div><div dir="auto"># GEOMETRY</div><div dir="auto">#=====================================================</div><div dir="auto"><br></div><div dir="auto">/gate/geometry/setMaterialDatabase <span class="Apple-tab-span" style="white-space:pre">                                </span>data/GateMaterials.db</div><div dir="auto"><br></div><div dir="auto"># World</div><div dir="auto">/gate/world/geometry/setXLength <span class="Apple-tab-span" style="white-space:pre">                          </span>10 cm</div><div dir="auto">/gate/world/geometry/setYLength <span class="Apple-tab-span" style="white-space:pre">                           </span>10 cm</div><div dir="auto">/gate/world/geometry/setZLength <span class="Apple-tab-span" style="white-space:pre">                           </span>10 cm</div><div dir="auto">/gate/world/setMaterial <span class="Apple-tab-span" style="white-space:pre">                                           </span>Air</div><div dir="auto">/gate/world/vis/setVisible <span class="Apple-tab-span" style="white-space:pre">                                          </span>1</div><div dir="auto">/gate/world/vis/forceWireframe</div><div dir="auto"><br></div><div dir="auto"># Voxel phantom</div><div dir="auto">/gate/world/daughters/name                      ct</div><div dir="auto">/gate/world/daughters/insert                    ImageRegularParametrisedVolume</div><div dir="auto">/gate/ct/geometry/setRangeToMaterialFile     <span class="Apple-tab-span" style="white-space:pre">        </span>data/range_geo.dat</div><div dir="auto">/gate/ct/geometry/setImage                   <span class="Apple-tab-span" style="white-space:pre">        </span>data/ct-gate.mhd</div><div dir="auto">/gate/ct/setSkipEqualMaterials <span class="Apple-tab-span" style="white-space:pre">                                 </span>1</div><div dir="auto">/gate/ct/vis/setVisible <span class="Apple-tab-span" style="white-space:pre">                                               </span>1</div><div dir="auto"># /gate/ct/vis/setColor <span class="Apple-tab-span" style="white-space:pre">                                                       </span>blue</div><div dir="auto">/gate/ct/vis/forceWireframe</div><div dir="auto"><br></div><div dir="auto"># /gate/geometry/rebuild</div><div dir="auto"><br></div><div dir="auto">#=====================================================</div><div dir="auto"># PHYSICS</div><div dir="auto">#=====================================================</div><div dir="auto"><br></div><div dir="auto">/gate/physics/addPhysicsList <span class="Apple-tab-span" style="white-space:pre">                                         </span>emstandard_opt3</div><div dir="auto">/gate/physics/addProcess <span class="Apple-tab-span" style="white-space:pre">                                                        </span>RadioactiveDecay #to generate decay process of F-18</div><div dir="auto"><br></div><div dir="auto">#=====================================================</div><div dir="auto"># DETECTORS</div><div dir="auto">#=====================================================</div><div dir="auto"><br></div><div dir="auto">/gate/actor/addActor                                DoseActor  doseDistribution</div><div dir="auto">/gate/actor/doseDistribution/attachTo    <span class="Apple-tab-span" style="white-space:pre">       </span>  <span class="Apple-tab-span" style="white-space:pre">         </span>ct</div><div dir="auto">/gate/actor/doseDistribution/stepHitType            random</div><div dir="auto">/gate/actor/doseDistribution/setSize                30 28.8 99 mm #Size in mm</div><div dir="auto">/gate/actor/doseDistribution/setPosition            0 0 0 cm # Origin</div><div dir="auto">/gate/actor/doseDistribution/setResolution          58 48 165 #Size (pixel)</div><div dir="auto">/gate/actor/doseDistribution/enableEdep             true</div><div dir="auto">/gate/actor/doseDistribution/enableUncertaintyEdep  true</div><div dir="auto">/gate/actor/doseDistribution/enableSquaredEdep      false</div><div dir="auto">/gate/actor/doseDistribution/enableDose             true #from true</div><div dir="auto">/gate/actor/doseDistribution/setDoseAlgorithm <span class="Apple-tab-span" style="white-space:pre">            </span>VolumeWeighting</div><div dir="auto"># /gate/actor/doseDistribution/enableDoseToWater      true #new set</div><div dir="auto">/gate/actor/doseDistribution/enableUncertaintyDose  true #from true</div><div dir="auto">/gate/actor/doseDistribution/enableSquaredDose      false</div><div dir="auto">/gate/actor/doseDistribution/enableNumberOfHits     true</div><div dir="auto">/gate/actor/doseDistribution/save                   output/output.mhd</div><div dir="auto"><br></div><div dir="auto">/gate/actor/addActor               <span class="Apple-tab-span" style="white-space:pre">                                       </span>SimulationStatisticActor stat</div><div dir="auto">/gate/actor/stat/save              <span class="Apple-tab-span" style="white-space:pre">                                 </span>output/stat.txt</div><div dir="auto">/gate/actor/stat/saveEveryNSeconds <span class="Apple-tab-span" style="white-space:pre">                                      </span>60</div><div dir="auto"><br></div><div dir="auto">#=====================================================</div><div dir="auto"># INITIALISATION</div><div dir="auto">#=====================================================</div><div dir="auto"><br></div><div dir="auto">/gate/run/initialize</div><div dir="auto"><br></div><div dir="auto">#=====================================================</div><div dir="auto"># SOURCE :</div><div dir="auto">#=====================================================</div><div dir="auto"><br></div><div dir="auto">#Description</div><div dir="auto"><br></div><div dir="auto">#Ion</div><div dir="auto">/gate/source/addSource<span class="Apple-tab-span" style="white-space:pre">                                                                                        </span>ion<span class="Apple-tab-span" style="white-space:pre"> </span>voxel</div><div dir="auto">/gate/source/ion/reader/insert <span class="Apple-tab-span" style="white-space:pre">                                                                    </span>image</div><div dir="auto">/gate/source/ion/imageReader/translator/insert <span class="Apple-tab-span" style="white-space:pre">                                    </span>linear</div><div dir="auto">/gate/source/ion/imageReader/linearTranslator/setScale<span class="Apple-tab-span" style="white-space:pre">                    </span>1. Bq</div><div dir="auto">/gate/source/ion/imageReader/readFile <span class="Apple-tab-span" style="white-space:pre">                                                     </span>data/pt-gate.mhd </div><div dir="auto">/gate/source/ion/imageReader/verbose <span class="Apple-tab-span" style="white-space:pre">                                                 </span>1</div><div dir="auto">/gate/source/ion/setPosition <span class="Apple-tab-span" style="white-space:pre">                                                                  </span>-15.0 -14.4 -49.5 mm</div><div dir="auto"><br></div><div dir="auto">/gate/source/ion/gps/particle <span class="Apple-tab-span" style="white-space:pre">                                                                        </span>ion</div><div dir="auto">/gate/source/ion/gps/ion <span class="Apple-tab-span" style="white-space:pre">                                                                            </span>9 18 0 0 #F-18</div><div dir="auto">/gate/source/ion/gps/energytype <span class="Apple-tab-span" style="white-space:pre">                                                          </span>Mono</div><div dir="auto">/gate/source/ion/gps/monoenergy <span class="Apple-tab-span" style="white-space:pre">                                                            </span>0. keV</div><div dir="auto">/gate/source/ion/gps/angtype <span class="Apple-tab-span" style="white-space:pre">                                                                     </span>iso</div><div dir="auto">/gate/source/ion/setForcedUnstableFlag <span class="Apple-tab-span" style="white-space:pre">                                                      </span>true </div><div dir="auto">/gate/source/ion/useDefaultHalfLife<span class="Apple-tab-span" style="white-space:pre">                                                               </span>6586 s</div><div dir="auto"><br></div><div dir="auto"><br></div><div dir="auto">/gate/source/ion/dump                                   <span class="Apple-tab-span" style="white-space:pre">             </span>1</div><div dir="auto"><br></div><div dir="auto"># /gate/source/list</div><div dir="auto"><br></div><div dir="auto">#=====================================================</div><div dir="auto"># RANDOM</div><div dir="auto">#=====================================================</div><div dir="auto">/gate/random/setEngineName MersenneTwister</div><div dir="auto">/gate/random/setEngineSeed auto</div><div dir="auto"><br></div><div dir="auto">#=====================================================</div><div dir="auto"># START</div><div dir="auto">#=====================================================</div><div dir="auto"><br></div><div dir="auto">/gate/application/noGlobalOutput</div><div dir="auto">/vis/enable</div><div dir="auto">/gate/application/setTotalNumberOfPrimaries <span class="Apple-tab-span" style="white-space:pre">                                 </span>500000 #acceptable uncertainty is at 500000 </div><div dir="auto">/gate/application/start</div><div dir="auto"><br></div>-- <br><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><div><div dir="ltr"><div><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div><b>연구중점교수, 분당서울대학교병원</b><br></div><div><b style="font-size:12.7273px">전화번호:</b><br></div><div><span style="font-size:12.7273px">(사무실) +82-31-787-2936</span></div><div><span style="font-size:12.7273px">(휴대전화) +82-10-8833-2806</span><br></div><div><span style="font-size:12.7273px"><b>팩스:</b> +82-31-787-4018</span></div><div><span style="font-size:12.7273px"><b>이메일:</b> </span><a href="mailto:hyuns@snu.ac.kr" style="font-size:12.7273px" target="_blank">hyuns@snu.ac.kr<br></a></div><div><br></div><div><b>Hyun Soo Park, PhD</b></div><div><b>--</b></div><div><b>Research professor</b></div><div>Department of Nuclear Medicine</div><div>Seoul National University Bundang Hospital, Seongnam, Korea</div><div><b style="font-size:12.7273px">Telephone:</b><br></div><div><div><span style="font-size:12.7273px">(Office) +82-31-787-2936</span></div><div><span style="font-size:12.7273px">(Mobile) +82-10-8833-2806</span><br></div><div><span style="font-size:12.7273px"><b>Fax:</b> +82-31-787-4018</span></div><div><span style="font-size:12.7273px"><b>email:</b> </span><a href="mailto:hyuns@snu.ac.kr" style="font-size:12.7273px" target="_blank">hyuns@snu.ac.kr</a></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>