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<p class="MsoNormal"><span lang="EN-US">Dear All,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">With respect to the message from Gunjan Kayal (http://lists.opengatecollaboration.org/pipermail/gate-users/2019-September/011088.html) , we continued on some tests regarding different GEANT4 versions with the use of the
ion source command in GATE.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">We’ve tested three Geant4/Gate combinations:<o:p></o:p></span></p>
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<tbody>
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<td width="215" nowrap="" valign="bottom" style="width:161.0pt;padding:0cm 3.5pt 0cm 3.5pt;height:15.0pt">
<p class="MsoNormal"><span style="color:black;mso-fareast-language:DE">Geant4 10.5.1 (Gate 8.2)<o:p></o:p></span></p>
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<tr style="height:15.0pt">
<td width="215" nowrap="" valign="bottom" style="width:161.0pt;padding:0cm 3.5pt 0cm 3.5pt;height:15.0pt">
<p class="MsoNormal"><span style="color:black;mso-fareast-language:DE">Geant4 10.5.0 (vGate 8.2)<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:15.0pt">
<td width="215" nowrap="" valign="bottom" style="width:161.0pt;padding:0cm 3.5pt 0cm 3.5pt;height:15.0pt">
<p class="MsoNormal"><span style="color:black;mso-fareast-language:DE">Geant4 10.3.3 (vGate 8.0)<o:p></o:p></span></p>
</td>
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<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Two scenarios were simulated and the dose was scored with the DoseActor and the S value was calculated. The obtained S values were subsequently compared to the literature.<o:p></o:p></span></p>
<p class="MsoListParagraph" style="text-indent:-18.0pt;mso-list:l0 level1 lfo2"><![if !supportLists]><span lang="EN-US"><span style="mso-list:Ignore">-<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span lang="EN-US">Unit density sphere of 60g (geometry and source defined in GATE)<o:p></o:p></span></p>
<p class="MsoListParagraph" style="text-indent:-18.0pt;mso-list:l0 level1 lfo2"><![if !supportLists]><span lang="EN-US"><span style="mso-list:Ignore">-<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span lang="EN-US">Voxelized human phantom for simulation of kidney S value
<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">This was done for three nuclides: Lutetium-177, Yttrium-90 and Iodine-131.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">The tables below show the percentage deviation of the simulated S value with GATE compared to the literature:<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-US">Sphere simulation<o:p></o:p></span></b></p>
<table class="MsoTableGrid" border="1" cellspacing="0" cellpadding="0" style="border-collapse:collapse;border:none">
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<p class="MsoNormal"><b><span lang="EN-US">Nuclide<o:p></o:p></span></b></p>
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<p class="MsoNormal"><b><span lang="EN-US">Version<o:p></o:p></span></b></p>
</td>
<td width="104" valign="top" style="width:77.95pt;border:solid windowtext 1.0pt;border-left:none;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><b><span lang="EN-US">Deviation [%]<o:p></o:p></span></b></p>
</td>
</tr>
<tr>
<td width="132" rowspan="3" valign="top" style="width:98.85pt;border:solid windowtext 1.0pt;border-top:none;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><b><span lang="EN-US">I-131<o:p></o:p></span></b></p>
</td>
<td width="180" valign="bottom" style="width:134.65pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span style="color:black;mso-fareast-language:DE">Geant4 10.5.1 (Gate 8.2)<o:p></o:p></span></p>
</td>
<td width="104" valign="top" style="width:77.95pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span lang="EN-US">0.9<o:p></o:p></span></p>
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<td width="180" valign="bottom" style="width:134.65pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span style="color:black;mso-fareast-language:DE">Geant4 10.5.0 (vGate 8.2)<o:p></o:p></span></p>
</td>
<td width="104" valign="top" style="width:77.95pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span lang="EN-US">6.4<o:p></o:p></span></p>
</td>
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<tr>
<td width="180" valign="bottom" style="width:134.65pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span style="color:black;mso-fareast-language:DE">Geant4 10.3.3 (vGate 8.0)<o:p></o:p></span></p>
</td>
<td width="104" valign="top" style="width:77.95pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span lang="EN-US">1.0<o:p></o:p></span></p>
</td>
</tr>
<tr>
<td width="132" rowspan="3" valign="top" style="width:98.85pt;border:solid windowtext 1.0pt;border-top:none;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><b><span lang="EN-US">Y-90<o:p></o:p></span></b></p>
</td>
<td width="180" valign="bottom" style="width:134.65pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span style="color:black;mso-fareast-language:DE">Geant4 10.5.1 (Gate 8.2)<o:p></o:p></span></p>
</td>
<td width="104" valign="top" style="width:77.95pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span lang="EN-US">-0.7<o:p></o:p></span></p>
</td>
</tr>
<tr>
<td width="180" valign="bottom" style="width:134.65pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span style="color:black;mso-fareast-language:DE">Geant4 10.5.0 (vGate 8.2)<o:p></o:p></span></p>
</td>
<td width="104" valign="top" style="width:77.95pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span lang="EN-US">-0.7<o:p></o:p></span></p>
</td>
</tr>
<tr>
<td width="180" valign="bottom" style="width:134.65pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span style="color:black;mso-fareast-language:DE">Geant4 10.3.3 (vGate 8.0)<o:p></o:p></span></p>
</td>
<td width="104" valign="top" style="width:77.95pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span lang="EN-US">-0.6<o:p></o:p></span></p>
</td>
</tr>
<tr>
<td width="132" rowspan="3" valign="top" style="width:98.85pt;border:solid windowtext 1.0pt;border-top:none;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><b><span lang="EN-US">Lu-177<o:p></o:p></span></b></p>
</td>
<td width="180" valign="bottom" style="width:134.65pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span style="color:black;mso-fareast-language:DE">Geant4 10.5.1 (Gate 8.2)<o:p></o:p></span></p>
</td>
<td width="104" valign="top" style="width:77.95pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span lang="EN-US">1.2<o:p></o:p></span></p>
</td>
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<p class="MsoNormal"><span style="color:red;mso-fareast-language:DE">Geant4 10.5.0 (vGate 8.2)<o:p></o:p></span></p>
</td>
<td width="104" valign="top" style="width:77.95pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span lang="EN-US" style="color:red">11.9<o:p></o:p></span></p>
</td>
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<p class="MsoNormal"><span style="color:black;mso-fareast-language:DE">Geant4 10.3.3 (vGate 8.0)<o:p></o:p></span></p>
</td>
<td width="104" valign="top" style="width:77.95pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span lang="EN-US">1.2<o:p></o:p></span></p>
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<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-US">Kidney simulation<o:p></o:p></span></b></p>
<table class="MsoTableGrid" border="1" cellspacing="0" cellpadding="0" style="border-collapse:collapse;border:none">
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<p class="MsoNormal"><b><span lang="EN-US">Nuclide<o:p></o:p></span></b></p>
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<p class="MsoNormal"><b><span lang="EN-US">Version<o:p></o:p></span></b></p>
</td>
<td width="104" valign="top" style="width:77.95pt;border:solid windowtext 1.0pt;border-left:none;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><b><span lang="EN-US">Deviation [%]<o:p></o:p></span></b></p>
</td>
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<td width="132" rowspan="3" valign="top" style="width:98.85pt;border:solid windowtext 1.0pt;border-top:none;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><b><span lang="EN-US">I-131<o:p></o:p></span></b></p>
</td>
<td width="180" valign="bottom" style="width:134.65pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span style="color:black;mso-fareast-language:DE">Geant4 10.5.1 (Gate 8.2)<o:p></o:p></span></p>
</td>
<td width="104" valign="top" style="width:77.95pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span lang="EN-US">-1.1<o:p></o:p></span></p>
</td>
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<tr>
<td width="180" valign="bottom" style="width:134.65pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span style="color:black;mso-fareast-language:DE">Geant4 10.5.0 (vGate 8.2)<o:p></o:p></span></p>
</td>
<td width="104" valign="top" style="width:77.95pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span lang="EN-US">3.8<o:p></o:p></span></p>
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<td width="180" valign="bottom" style="width:134.65pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span style="color:black;mso-fareast-language:DE">Geant4 10.3.3 (vGate 8.0)<o:p></o:p></span></p>
</td>
<td width="104" valign="top" style="width:77.95pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span lang="EN-US">-1.2<o:p></o:p></span></p>
</td>
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<tr>
<td width="132" rowspan="3" valign="top" style="width:98.85pt;border:solid windowtext 1.0pt;border-top:none;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><b><span lang="EN-US">Y-90<o:p></o:p></span></b></p>
</td>
<td width="180" valign="bottom" style="width:134.65pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span style="color:black;mso-fareast-language:DE">Geant4 10.5.1 (Gate 8.2)<o:p></o:p></span></p>
</td>
<td width="104" valign="top" style="width:77.95pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span lang="EN-US">1.8<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="color:black;mso-fareast-language:DE">Geant4 10.5.0 (vGate 8.2)<o:p></o:p></span></p>
</td>
<td width="104" valign="top" style="width:77.95pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span lang="EN-US">1.8<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="color:black;mso-fareast-language:DE">Geant4 10.3.3 (vGate 8.0)<o:p></o:p></span></p>
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<p class="MsoNormal"><span lang="EN-US">1.8<o:p></o:p></span></p>
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<p class="MsoNormal"><b><span lang="EN-US">Lu-177<o:p></o:p></span></b></p>
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<p class="MsoNormal"><span style="color:black;mso-fareast-language:DE">Geant4 10.5.1 (Gate 8.2)<o:p></o:p></span></p>
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<p class="MsoNormal"><span lang="EN-US">2.6<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="color:red;mso-fareast-language:DE">Geant4 10.5.0 (vGate 8.2)<o:p></o:p></span></p>
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<p class="MsoNormal"><span lang="EN-US" style="color:red">12.5<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="color:black;mso-fareast-language:DE">Geant4 10.3.3 (vGate 8.0)<o:p></o:p></span></p>
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<p class="MsoNormal"><span lang="EN-US">2.5<o:p></o:p></span></p>
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<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">The finding that Geant4 version 10.5.0 is showing large discrepancies was already pointed out by Gunjan who was simulating a different scenario with Lu-177 dose point kernels. But it is interesting to see, that the deviation
is varying for different nuclides. We assume that this finding is related to the different decay schemes of the three investigated nuclides. Unfortunately, we could not find a hint in the Geant4 release notes or in the Geant4 user forum where this deviation
for Geant4 version 10.5.0 is coming from. <o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">We therefore recommend <b><u>NOT</u></b> to use Geant4 version 10.5.0, when using the ion source command! And to remind you, the virtual GATE8.2 is installed with Geant4 10.5.0!<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Any help to find out the reason for the discrepancies is highly welcome!<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Best,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Julia<o:p></o:p></span></p>
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