<html dir="ltr">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1">
<style>
<!--
@font-face
{font-family:"Cambria Math"}
@font-face
{font-family:Calibri}
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0cm;
margin-bottom:.0001pt;
font-size:11.0pt;
font-family:"Calibri","sans-serif"}
a:link, span.MsoHyperlink
{color:#0563C1;
text-decoration:underline}
a:visited, span.MsoHyperlinkFollowed
{color:#954F72;
text-decoration:underline}
span.EmailStyle17
{font-family:"Calibri","sans-serif";
color:windowtext}
.MsoChpDefault
{font-family:"Calibri","sans-serif"}
@page WordSection1
{margin:70.85pt 70.85pt 70.85pt 70.85pt}
-->
</style><style id="owaParaStyle" type="text/css">P {margin-top:0;margin-bottom:0;}</style>
</head>
<body ocsi="0" fpstyle="1" lang="FR" link="#0563C1" vlink="#954F72">
<div style="direction: ltr;font-family: Tahoma;color: #000000;font-size: 10pt;"><font size="2">Dear Mahdjoub,<br>
<br>
It is really difficult to modelize the real shape of nanoparticles in a voxelized phantom because of the difference between scales.<br>
I tried Mesbahi et al. method of meshing (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648909/) but it was impossible to reproduce a similar geometry, with 10^9 NPs using Gate.<br>
<br>
Finally, I had to create new materials in the GateMaterialDatabase in order to mimic an homogeneous mixture of gold nanoparticles at several concentrations, and water (or soft tissue). We had good results in voxelized phantoms created in Gate, but it was a
little more difficult in CT-based phantoms of real patients.<br>
<br>
If you want to work at the nanometric scale to study Auger effect at a few nanometers from nanoparticles, you can create a 3D meshing with a few nanoparticles in a micrometric
</font><font size="2">phantom (or just one nanoparticle in a spherical or cubic phantom). But in my opinion, it is not realistic to reproduce the real layout of nanoparticles in a human scale phantom.<br>
<br>
Best regards,<br>
<br>
Sylvain<br>
</font>
<div><br>
<div style="font-family:Tahoma; font-size:13px">
<div class="BodyFragment"><font size="2"><span style="font-size:10pt">
<div class="PlainText"><font size="2"><span style="font-size:10pt">-- <br>
Sylvain Reuzé<br>
PhD student in Medical Physics<br>
INSERM U1030 "Molecular Radiotherapy"<br>
GUSTAVE ROUSSY<br>
Radiotherapy - Medical Physics department<br>
Phone: (+0033) 1.42.11.54.06<br>
www.gustaveroussy.fr</span></font></div>
</span></font></div>
</div>
</div>
<font size="2"><br>
</font>
<div style="font-family: Times New Roman; color: #000000; font-size: 16px">
<hr tabindex="-1">
<div style="direction: ltr;" id="divRpF698063"><font face="Tahoma" color="#000000" size="2"><b>De :</b> gate-users-bounces@lists.opengatecollaboration.org [gate-users-bounces@lists.opengatecollaboration.org] de la part de Mahdjoub Hamdi [mahdjoub.hamdi@hotmail.fr]<br>
<b>Date d'envoi :</b> vendredi 26 février 2016 20:47<br>
<b>À :</b> gate-users@lists.opengatecollaboration.org<br>
<b>Objet :</b> [Gate-users] Gold nano particles in a voxelized phantom<br>
</font><br>
</div>
<div></div>
<div>
<div class="WordSection1">
<p class="MsoNormal"><span lang="EN-US">Good afternoon everyone,</span></p>
<p class="MsoNormal"><span lang="EN-US"> </span></p>
<p class="MsoNormal"><span lang="EN-US">Does anyone know any think useful on how to model a gold nano-particles in a voxelized phantom?</span></p>
<p class="MsoNormal"><span lang="EN-US"> </span></p>
<p class="MsoNormal"><span lang="EN-US">Cordially,</span></p>
<p class="MsoNormal"><span lang="EN-US">Mahdjoub.</span></p>
<p class="MsoNormal"> </p>
</div>
</div>
</div>
</div>
</body>
</html>